Dialyse aktuell 2009; 13(5): 242-247
DOI: 10.1055/s-0029-1225946
Dialyse

© Georg Thieme Verlag Stuttgart · New York

Proteinmalnutrition bei Dialysepatienten – Diagnose und Therapie

Protein malnutrition and dialysis patients – Diagnosis and therapyHelmut Mann1
  • 1Institut für angewandte Nephrologie, Aachen
Further Information

Publication History

Publication Date:
17 June 2009 (online)

Eine Proteinmalnutrition tritt bei 20–35 % aller Dialysepatienten auf und trägt zu einer erhöhten Mortalität bei. Die Ursachen können organische und psychische Störungen, eine inadäquate Dialysetherapie sowie eine unpassende medikamentöse Behandlung sein. Die Therapie der Proteinmangelernährung besteht in einer sorgfältigen Diätberatung unter Berücksichtigung der spezifischen Erfordernisse eines Dialysepatienten, in der Optimierung der Dialysebehandlung sowie in der enteralen oder parenteralen Ernährung mit speziellen Nährlösungen, die auf die Dialysetherapie ausgerichtet sind.

Protein malnutrition can be seen in 20–35 % of all chronic dialysis patients. It is one cause of the increased mortality of these patients. The causes of protein malnutrition are inadequate dialysis prescription, inadequate drug therapy, physiological and psychological disorders. The therapy of malnutrition consists of deliberate dietetic counselling, optimization of the dialysis therapy and enteral or parenteral nutrition with specific nutrients adapted to the conditions of the dialysis therapy.

Literatur

  • 1 Aparicio M, Cano N, Chauveau P.. Nutritional status of haemodialysis patients: a French national cooperative study. French Study Group for Nutrition in Dialysis.  Nephrol Dial Transplant. 1999;  14 1679-1686
  • 2 Ikizler TA, Flakoll PJ, Parker RA, Hakim RM.. Amino acid and albumin losses during hemodialysis.  Kidney Int. 1994;  46 830-837
  • 3 Fung F, Sherrad DJ, Gillen DL. et al. . Increased risk for cardiovascular mortality among malnourished end–stage renal patients.  Am J Kidney Dis. 2002;  40 307-314
  • 4 Herselman M, Moosa MR, Kotze TJ. et al. . Protein–energy malnutrition as a risk factor for increased morbidity in long–term hemodialysis patients.  J Ren Nutr. 2000;  10 7-15
  • 5 Johansen KL, Kaysen GA, Young BS. et al. . Longitudinal study of nutritional status, body composition and physical function in hemodialysis patients.  A J Clin Nutr. 2003;  77 842-846
  • 6 Kalantar–Zadeh K, Supasyndh O, Lehn RS. et al. . Normalized protein nitrogen appearance is correlated with hospitalization and mortality in hemodialysis patients with Kt/V greater than 1,20.  J Ren Nutr. 2003;  13 15-25
  • 7 Mafra D, Guebre–Egziabher F, Fouque D.. Body mass index, muscle and fat in chronic kidney disease: questions about survival.  Nephrol Dial Transplant. 2008;  23 2461-2466
  • 8 Pifer TB, McCullough KP, Port FK. et al. . Mortality risk in hemodialysis patients and changes in nutritional disorders: DOPPS.  Kidney Int. 2002;  62 2238-2245
  • 9 Capelli JP, Kushner H, Camiscioli TC. et al. . Effect of intradialytic parenteral nutrition on mortality rates in end–stage renal disease care.  Am J Kid Dis. 1994;  23 808-816
  • 10 Kloppenburg WD, Stegeman CA, Hovinga TK. et al. . Effect of prescribing a high protein diet and increasing the dose of dialysis on nutrition in stable chronic haemodialysis patients: a randomized, controlled trial.  Nephrol Dial Transplant. 2004;  9 1212-1223
  • 11 Kopple JD.. National kidney foundation KDOQI clinical practice guidelines for nutrition in chronic renal failure.  Am J Kid Dis. 2001;  37
  • 12 Pupim LB, Flakoll PJ, Brouillette JR. et al. . Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients.  J Clin Invest. 2002;  110 483-492
  • 13 Cano NJ, Fouque D, Roth H. et al. . Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis outcome: a 2–year multicenter, prospective, randomized study.  J Am Soc Nephrol. 2007;  18 2583-2591
  • 14 Jones CH, Wolfenden RC, Wells LM.. Is subjective global assessment a reliable measure of nutritional status in hemodialysis?.  J Ren Nutr. 2004;  14 26-30
  • 15 Lazarus JM.. Recommended criteria for initiating and discontinuing intradialytic parenteral nutrition therapy.  Am J Kid Dis. 1999;  33 211-216
  • 16 Terrier N, Jaussent I, Dupuy AM. et al. . Creatinine index and transthyretin as additive predictors of mortality in haemodialysis patients.  Nephrol Dial Transplant. 2007;  23 345-353
  • 17 Maggiore Q, Nigrelli S, Ciccarelli C. et al. . Nutritional and prognostic correlates of bioimpedance indexes in hemodialysis patients.  Kidney Int. 1996;  50 2103-2108
  • 18 Fouque D, Vennegor M, Ter P Wee. et al. . EBPG guideline on nutrition.  Nephrol Dial Transplant. 2007;  22 45-87
  • 19 Druml W, Kuhlmann M, Mann H, Hörl W.. DGEM–Leitlinie Enterale Ernährung: Nephrologie.  Aktuel Ernaehr Med. 2003;  28

Korrespondenz

Prof. Dr. Helmut Mann

Institut für angewandte Nephrologie e. V.

Schurzelter–Str. 564

52074 Aachen

Email: helmut.mann@t-online.de