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Synfacts 2010(6): 0678-0678  
DOI: 10.1055/s-0029-1219972
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric Intramolecular Cyanoamidation

Contributor(s): Hisashi Yamamoto, Zhi Li
V. J. Reddy, C. J. Douglas*
University of Minnesota, Minneapolis, USA
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

This work described a highly enantioselective palladium-catalyzed intramolecular cyanoamidation which generates 3,3-disubstituted oxindoles. Three asymmetric syntheses of natural indole alkaloids were also achieved using this method.