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Synfacts 2010(6): 0733-0733  
DOI: 10.1055/s-0029-1219895
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Polymer-Supported Nitrosation Reagent of Amines

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
D. Roche*, C. Lardy, L. Tournier, M. Prunier, E. Valeur
Merck Serono, Chilly-Mazarin, Edelris, Lyon and Groupe Solabia, Anet, France
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Polymer-supported nitrosation ­reagents (PS-SNAP, PEG-SNAP, PS-5; SNAP = S-nitroso-N-acetylpenicillamine) were prepared from PS aminomethyl resin or PEG aminomethyl resin in two steps that were used for nitrosation of sec-amines. Thus, the nitrosation of amines 1 was performed with PS-SNAP to give the corresponding N-nitroso products 2 (8 examples, 67-91% conversion).