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Synfacts 2010(6): 0725-0725  
DOI: 10.1055/s-0029-1219887
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Propargylamines with Fe3O4 Nanoparticles

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
B. Sreedhar*, A. S. Kumar, P. S. Reddy
Indian Institute of Chemical Technology, Hyderabad, India
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Magnetically separable Fe3O4 nanoparticles catalyzed the three-component coupling of aldehydes 1, amines 2, and terminal alkynes 3 to afford the corresponding propargyl­amines 4 (18 examples, up to 92% yield, eq. 1). The reaction of 1,3-diethynylbenzene, cyclohexanecarboxaldehyde, and piperidine gave mono- and disubstituted products 4g and 4h in a ratio of 1:3 (eq. 2).