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Synfacts 2010(5): 0588-0588  
DOI: 10.1055/s-0029-1219659
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Simple Copper Chloride Catalyzed Arylation of Amines and Pyrrole in Water

Contributor(s): Paul Knochel, Andrei Gavryushin
H.-J. Xu, F.-Y. Zheng, Y.-F. Liang, Z.-Y. Cai, Y.-S. Feng*, D.-Q. Che*
Hefei University of Technology and Zhejiang Jiuzhou Pharmaceutical Co., Taizhou, P. R. of China
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Publikationsdatum:
22. April 2010 (online)

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Significance

The authors report a simple and environmentally benign protocol for the arylation of amines and pyrrole by variously substituted aryl and heteroaryl bromides and iodides in water using ligandless copper(I) as a catalyst and Bu4NOH as a base. The simplicity and versatility of the ­reaction makes it well suitable for industrial processes.