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Synfacts 2010(3): 0312-0312  
DOI: 10.1055/s-0029-1219404
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Protocol for the Titanium-Catalyzed Asymmetric Cyanation of Imines

Contributor(s): Mark Lautens, David A. Candito
A. M. Seayad*, B. Ramalingam, K. Yoshinaga, T. Nagata, C. L. L. Chai*
Institute of Chemical and Engineering Sciences and Mitsui Chemicals Asia Pacific Ltd., Singapore, Republic of Singapore
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

The authors report an efficient ­protocol for the titanium-catalyzed cyanation of imines providing α-cyano amines in excellent yields and selectivity. Cyanation has been extensively investigated for the past decade (Chem. Rev. 2003, 103, 2795-2828).