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Synfacts 2010(3): 0347-0347  
DOI: 10.1055/s-0029-1219305
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Coupling of sec-Benzylic Bromides with Grignard Reagents

Contributor(s): Paul Knochel, Andrei Gavryushin
A. López-Pérez, J. Adrio*, J. C. Carretero*
Universidad Autónoma de Madrid, Spain
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

The authors report a simple procedure for the palladium-catalyzed cross-coupling of secondary benzylic halides with aryl and alkenyl Grignard reagents, allowing to prepare polysubstituted diarylmethanes and allyl benzenes. This ­reaction proceeds with complete inversion of the configuration and tolerates useful functional groups.