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Synfacts 2010(3): 0304-0304  
DOI: 10.1055/s-0029-1219266
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Calixarenes

Contributor(s): Timothy M. Swager, Jose M. Lobez
V. Gopalsamuthiram, A. V. Predeus, R. H. Huang, W. D. Wulff*
Michigan State University, East Lansing, USA
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

Optically active calix[4]arenes where the chirality comes from the substitution of the methylene bridges are presented for the first time. Usual strategies for the synthesis of optically active calixarenes come from substitution either on the benzene rings or on the alkoxy substituents. This family of molecules is relevant as scaffolds for chiral recognition events.