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Synfacts 2010(3): 0263-0263  
DOI: 10.1055/s-0029-1219254
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chloropeptin II

Contributor(s): Steven V. Ley, Philippa B. Cranwell
J. Garfunkle, F. S. Kimball, J. D. Trzupek, S. Takizawa, H. Shimamura, M. Tomishima, D. L. Boger*
The Scripps Research Institute, La Jolla, USA
Further Information

Publication History

Publication Date:
18 February 2010 (online)

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Significance

Chloropeptin II (complestatin) was isolated from Streptomyces lavendulae and has been shown to have activity against HIV gp120-CD4 binding. There have been no previous syntheses of chloropeptin II.