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Synfacts 2010(2): 0244-0244  
DOI: 10.1055/s-0029-1219044
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Propargylic Amines with PbS-Au/C in Water

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
L. L. Chng, J. Yang, Y. Wei, J. Y. Ying*
Institute of Bioengineering and Nanotechnology, The Nanos, Singapore
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Publikationsdatum:
21. Januar 2010 (online)

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Significance

A PbS-Au nanocomposite supported on carbon powder (PbS-Au/C) catalyzed the three-component coupling reaction of aldehydes 1, secondary amines 2, and terminal alkynes 3 in water to give the corresponding ­propargylic amines 4 in up to 95% isolated yield (32 examples).