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Synfacts 2010(2): 0129-0129
DOI: 10.1055/s-0029-1219030
DOI: 10.1055/s-0029-1219030
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of m-Prostaglandin E Synthase-1 Inhibitor MK-7285
F. Gosselin*, S. Lau, C. Nadeau, T. Trinh, P. D. O’Shea, I. W. Davies
Merck Frosst Center for Therapeutic Research, Kirkland, Canada and Merck Research Laboratories, Rahway, USA
Further Information
Publication History
Publication Date:
21 January 2010 (online)
Significance
Prostaglandin E synthase-1 converts PGH2 into PGE2, a key step in the propagation of inflammatory stimuli. MK-7285, a selective inhibitor of PGES-1, is a candidate for the treatment of osteoarthritis, rheumatoid arthritis, and pain.