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Synfacts 2010(2): 0139-0139  
DOI: 10.1055/s-0029-1219028
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Hirsutellone B

Contributor(s): Philip Kocienski
K. C. Nicolaou*, D. Sarlah, T. R. Wu, W. Zhan
The Scripps Research Institute and University of California at San Diego, La Jolla, USA
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

Hirsutellone B is a metabolite of the insect pathogenic fungus Hirsutella nivea. It is ­active against Mycobacterium tuberculosis. This synthesis is noteworthy for the use of cascade ­reactions to create the tricyclic ring system.