Synthesis of Subglutinol A

doi:10.1055/s-0029-1217580

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Synfacts 2009(8): 0819-0819
DOI: 10.1055/s-0029-1217580

Synthesis of Natural Products and Potential Drugs

Synthesis of Subglutinol A

Contributor(s): Philip Kocienski
H. Kim, J. B. Baker, S.-U. Lee, Y. Park, K. L. Bolduc, H.-B. Park, M. G. Dickens, D.-S. Lee, Y. Kim, S. H. Kim*, J. Hong*
Duke University, Durham, USA; Korea Research Institute of Chemical Technology and Chungnam National University, Daejon, Seoul National University, and Gwangju Institute of Science & Technology, Korea

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Publication History

Publication Date:
23 July 2009 (online)

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Significance

Subglutinol A, a non-toxic metabolite of the fungus Fusarium subglutinans, displays immunosuppressive activity (IC₅₀ = 25 nM, MLR assay) and some osteogenic (i.e. bone-forming) efficacy, unlike the immunosuppressants cyclo-sporin and FK-506 which can cause osteoporosis.