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Synfacts 2009(7): 0707-0707  
DOI: 10.1055/s-0029-1217241
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Coralydine

Contributor(s): Philip Kocienski, Indu Dager
M. Chaumontet, R. Piccardi, O. Baudoin*
Université Claude Bernard Lyon 1, Villeurbanne and Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publikationsdatum:
22. Juni 2009 (online)

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Significance

The synthesis portrayed here utilizes a Pd-catalyzed C(sp³)-H activation to form benzocyclobutene ester B. Various 3,4-dihydro-isoquinolines are synthesized using C-H ­activation and a tandem electrocyclic ring opening-6π-electrocyclization of different iminobenzocyclobutenes.