A 49-year-old woman was diagnosed as having a right invasive ductal
breast cancer with right maxillary lymph nodes metastasis (pT2N3M0, stage IIIc)
in 2006. She underwent a partial mastectomy followed by adjuvant chemotherapy.
The disease remained stable until 2008. In May 2008, she was admitted to
hospital for investigations because of abdominal pain. Physical examination and
laboratory tests showed no remarkable abnormalities. Colonoscopy demonstrated
a
2-cm elevated erythematous erosion in the transverse colon near the hepatic
flexure ([Fig. 1]). We carried out multiple
forceps biopsies of the colonic erosion. Microscopic examination of the biopsy
specimens revealed nests of pleomorphic tumor cells, with slightly eccentric
nuclei, in the lamina propria ([Fig. 2]).
Immunohistochemical study of the tumor cells was positive for cytokeratin 7
([Fig. 3]) and negative for cytokeratin 20, a
pattern similar to that of the primary tumor. On the basis of the pathological
features, a diagnosis of metastatic breast cancer was made.
Fig. 1 A 2-cm elevated,
erythematous erosion near the hepatic flexure in the transverse colon,
visualized on colonoscopy.
Fig. 2 Histological examination
of a biopsy specimen from the colonic erosion showing nests of pleomorphic
tumor cells in the lamina propria. The cells have slightly eccentric nuclei
(hematoxylin and eosin, magnification × 400).
Fig. 3 Immunohistochemical
evaluation showing positivity for cytokeratin 7
(magnification × 400).
Breast cancer is the second most common cancer worldwide. Whereas
the lung, liver, and the bones are common sites for distant metastasis in women
with breast cancer, metastasis to the gastrointestinal tract is an uncommon
event [1]. When gastrointestinal metastasis does occur,
the upper gastrointestinal tract is more frequently involved. In contrast,
colonic metastasis from a breast cancer is rare [2]. The
lobular, infiltrating type of carcinoma of the breast apparently has a greater
predilection for the gastrointestinal tract than the ductal type
[3]. Gastrointestinal metastasis of breast cancer is
difficult to diagnose early because of the nonspecific nature of the symptoms
[4], and, therefore, the prognosis is usually poor.
Surgical intervention does not seem to improve survival except in the subgroup
of women in whom this is the only site of metastatic spread [5]. In conclusion, despite isolated gastrointestinal
metastasis being a rare occurrence, metastatic disease should be considered
whenever a woman with breast cancer experiences gastrointestinal symptoms.
Endoscopy_UCTN_Code_CCL_1AD_2AB
