Planta Med 2010; 76(4): 365-368
DOI: 10.1055/s-0029-1186192
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Leishmanial Lindenane Sesquiterpenes from Hedyosmum angustifolium

Lucia Acebey1 , 2 , 3 , Valérie Jullian2 , 3 , Denis Sereno4 , Séverine Chevalley2 , 3 , Yannick Estevez2 , 3 , Claude Moulis2 , 3 , Stephan Beck5 , Alex Valentin2 , 3 , Alberto Gimenez1 , Michel Sauvain2 , 3
  • 1Instituto de Investigaciones Fármaco Bioquímicas, Facultad de Ciencias Farmacéuticasy Bioquímicas, Universidad Mayor de San Andrés, La Paz, Bolivia
  • 2Université de Toulouse, UPS, UMR 152 (Laboratoire de pharmacochimie des substances naturelles et pharmacophores redox), Toulouse, France
  • 3Institut de Recherche pour le Développement (IRD), UMR 152, Toulouse, France
  • 4UR 016 IRD, BP 64501, Montpellier Cedex 5, France
  • 5Herbario Nacional de Bolivia, Universidad Mayor de San Andrés, Cota Cota, La Paz, Bolivia
Weitere Informationen

Publikationsverlauf

received May 4, 2009 revised August 19, 2009

accepted September 11, 2009

Publikationsdatum:
14. Oktober 2009 (online)

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Abstract

The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of Hedyosmum angustifolium. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the first time from a natural source (hedyosmone, 2), and three known sesquiterpenes (onoseriolide, 3; chloranthalactone A, 4; and spathulenol, 5) that had not been previously isolated from H. angustifolium. The biological activities of 15 showed that onoseriolide (3) was the most active compound against axenic amastigotes from Leishmania amazonensis and L. infantum. Moreover, it was still active on the intramacrophagic amastigotes of L. infantum. The isolated compounds have also been tested on Plasmodium falciparum and against various mammalian cell lines.

References

Michel Sauvain

Institut de Recherche pour le Développement
UMR-152
Mission IRD

Casilla 18

1209 Lima

Peru

Telefon: + 51 14 81 17 94

Fax: + 51 14 42 32 23

eMail: michel.sauvain@ird.fr