Lupane-Type Triterpene Glycosides from the Leaves of Acanthopanax koreanum and Their In Vitro Cytotoxicity

Abstract

Three new lupane triterpene glycosides, acankoreosides J–L (1–3), were isolated from the leaves of Acanthopanax koreanum. Based on the spectroscopic data, the chemical structures were determined as 3α-hydroxy-20-oxo-30-norlupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (1); 3α,20,29-trihydroxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (2); and (20S)-3α-hydroxy-29,29-dimethoxylupane-23,28-dioic 28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl ester (3). Compounds 1−3 were evaluated for their cytotoxicity and showed moderate activity against four cell lines, A549 (lung), HL-60 (leukemia), MCF-7 (breast), and U937 (leukemia), with IC₅₀ values of 23.4, 36.5, 22.6, and 18.5 µM for 1; 6.8, 18.6, 23.1, and > 100 µM for 2; and 28.9, 21.8, 11.0, and 27.5 µM for 3, respectively.

Key words

Acanthopanax koreanum - Araliaceae - lupane glycoside - acankoreoside - in vitro cytotoxic activity

References

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