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DOI: 10.1055/s-0028-1112204
© Georg Thieme Verlag KG Stuttgart · New York
New Alkaloids from Forsythia suspensa and their Anti-Inflammatory Activities
Publication History
Received: September 25, 2008
Revised: October 26, 2008
Accepted: November 1, 2008
Publication Date:
15 January 2009 (online)
Abstract
Two new alkaloids, named suspensine A (1) and (−)-7′-O-methylegenine (2), along with two known alkaloids, (−)-egenine (3) and (−)-bicuculline (4), were isolated from the ethanolic extract of the fruits of Forsythia suspensa. Their structures were established by means of chemical methods and spectroscopic analyses. In vitro, four alkaloids showed anti-inflammatory activities, with inhibition rates of release of β-glucuronidase from polymorphonuclear leukocytes of rats being in the range 34.8 % – 39.6 % at 10 μM.
Key words
Forsythia suspensa - Oleaceae - suspensine A - (−)-7′-O-methylegenine - anti-inflammatory activity
References
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Sheng-Jun Dai
School of Pharmaceutical Science
Yantai University
Yantai 264005
People′s Republic of China
Phone: +86-535-670-6025
Fax: +86-535-670-6036
Email: daishengjun_9@hotmail.com