manuelletherapie 2009; 13(4): 167-172
DOI: 10.1055/s-0028-1109756
Expertenforum

© Georg Thieme Verlag KG Stuttgart · New York

Übersicht über Schmerzmechanismen: Implikationen für Diagnose und physiotherapeutische Behandlung „problematischer” Schmerzpatienten

Overview of Pain Mechanisms: Implications for the Diagnosis and Management of ”Problem” Pain Patients with Physical TherapyM. Zusman1
  • 1School of Physiotherapy, Curtin University of Technology, Perth, Australien
Further Information

Publication History

Manuskript eingetroffen: 2.2.2009

Manuskript akzeptiert: 8.05.2009

Publication Date:
22 September 2009 (online)

Zusammenfassung

Das häufigste auftretende und zu behandelnde Problem in der klinischen Praxis von Physiotherapeuten ist Schmerz. Dies betrifft oft bestimmte Arten von besonders „schwierigen” Schmerzsyndromen ohne zugrundeliegende organische Ursachen sowie wiederkehrende anhaltende Schmerzstörungen.

Die vorliegende Arbeit liefert einen Überblick über periphere und zentralnervöse Mechanismen bei entzündlichen und neuropathischen Schmerzen.

Abstract

The most common problem physiotherapists encounter in clinical practice and are required to treat is pain. This often involves certain types of particularly ”difficult” pain syndromes without underlying organic causes as well as prolonged relapsing pain disorder.

This article gives an overview of peripheral and central nervous system mechanisms for inflammatory and neuropathic pain.

Literatur

  • 1 Amir R, Argoff C, Bennett G. et al . The role of sodium channels in chronic inflammatory and neuropathic pain.  The Journal of Pain. 2006;  7 S1-S29
  • 2 Barad M. Fear extinction in rodents: basic insight to clinical promise.  Current Opinion in Neurobiology. 2005;  15 710-715
  • 3 Bennett G. Can we distinguish between inflammatory and neuropathic pain?.  Pain Research and Management. 2006;  11 11A-15A
  • 4 Bouton M E. Context, ambiguity and unlearning: sources of relapse after behavioural extinction.  Biological Psychiatry. 2002;  52 976-986
  • 5 Campbell J, Meyer R. Mechanisms of neuropathic pain.  Neuron. 2006;  52 77-92
  • 6 Clauw D J, Crofford L J. Chronic widespread pain and fibromyalgia: what we know, and what we need to know.  Best Practice & Research Clinical Rheumatology. 2003;  17 685-701
  • 7 Costigan M, Wollf C J. Pain: molecular mechanisms.  The Journal of Pain. 2000;  1 35-44
  • 8 Devor M. Sodiun channels and mechanisms of neuropathic pain.  The Journal of Pain. 2006;  7 S3-S12
  • 9 Dray A. Pharmacology of inflammatory pain. Merskey H, Loeser JD, Dubner R The Paths of Pain 1975 – 2005 Seattle; IASP 2005
  • 10 Gold M S. Molecular basis of receptors. Merskey H, Loeser JD, Dubner R The Paths of Pain 1975 – 2005 Seattle; IASP 2005
  • 11 Ji R R, Kohno T, Moore K A. et al . Central sensitisation and LTP: do pain and memory share similar mechanisms?.  Trends in Neurosciences. 2003;  26 696-706
  • 12 Kawasaki Y, Kohno T, Zhang Z Y. et al . Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and src contribute to C-fiber-induced ERK activation and camp response element binding protein phosphorylation in dorsal horn neurons, leading to central sensitisation.  The Journal of Neuroscience. 2004;  24 8310-8321
  • 13 Maren S. Synaptic mechanisms of associative memory in the amygdala.  Neuron. 2005;  47 783-786
  • 14 Neugebauer V. Subcortical processing of nociceptive information: basal ganglia and amygdala. Cervero F, Jensen TS Handbook of Clinical Neurology Amsterdam; Elsevier 2006
  • 15 Senapati A K, Huntington P J, Peng Y B. Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex.  Brain Research. 2005;  1036 173-179
  • 16 Treede R D, Klein T, Magerl W. Pain memory and central sensitisation in humans. Flor H, Kalso E, Dostrovsky JO Proceedings of the 11th World Congress on Pain Seattle; IASP 2006
  • 17 Turk D. Understanding pain sufferers: the role of cognitive processes.  The Spine Journal. 2004;  4 1-7
  • 18 Wall P D. Interview: Ready for action (McCrone J).  New Scientist. 1999;  5 48-51
  • 19 Woolf C J. Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy.  Life Sciences. 2004;  74 2605-2610
  • 20 Woolf C J. Pain: moving from symptom control toward mechanism-specific pharmacologic management.  Annals of Internal Medicine. 2004;  104 441-451
  • 21 Zusman M. Associative memory for movement-evoked chronic back pain and its extinction with musculoskeletal physiotherapy.  Physical Therapy Reviews. 2008;  13 57-68
  • 22 Zusman M. Mechanisms of peripheral neuropathic pain: implications for musculoskeletal physiotherapy.  Physical Therapy Reviews. 2008;  13 313-323

Max Zusman,

DipPT (WAust) GradDipHlthSc (WAIT) MAppSc(Curtin), School of Physiotherapy, Curtin University of Technology

Perth WA 6845

Australia

Email: M.Zusman@curtin.edu.au

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