Management der fetalen Ösophagusatresie

Das prä-, peri- und postnatale Management der Ösophagusatresie stellt hohe Anforderungen an die Perinatalmedizin. Oft lässt sich diese seltene Fehlbildung präpartal nicht sicher diagnostizieren. Nach der Entbindung sind eine rasche Diagnostik und Therapie wichtig, um durch Vermeidung einer Aspirationspneumonie ein gutes „Outcome” für das Neugeborene zu erzielen. Damit ist die Ösophagusatresie ein gutes Beispiel für die Wichtigkeit einer eingespielten interdisziplinären Zusammenarbeit in einem Perinatalzentrum.

Literatur

• 1 Kretz F-J, Becke K. Anästhesie und Intensivmedizin bei Kindern. Stuttgart: Thieme; 2007: 236
• 2 Sparey C, Jawaheer G, Barrett A M et al. Esophageal atresia in the northern region congenital anomaly survey, 1985–1997: prenatal diagnosis and outcome.  Am J Obstet Gynecol. 2000;  182 427-431
• 3 Spitz L. Oesophageal atresia.  Orphant J Rare Dis. 2007;  11 24
• 4 Orford J, Glasson M, Beasly S et al. Oesophageal atresia in twins.  Pediatr Surg Int. 2000;  16 541-545
• 5 Genevieve D, de Pontual L, Amiel J et al. An overview of isolated and syndromic oesophageal atresia.  Clin Genet. 2007;  71 392-399
• 6 Ioannides A S, Henderson D J, Spitz L et al. Role of Sonic hedgehog in the development of the trachea and oesophagus.  Pediatr Surg. 2003;  38 29-36
• 7 Spilde T L, Bhatia A M, Mehta S S et al. Defective sonic hedgehog in esophageal atresia with tracheoesophageal fistula.  J Pediatr Surg. 2003;  134 345-350
• 8 Shaw-Smith C J. Oesophageal atresia, tracheo-oesophageal fistula and the VACTERL association: review of genetics and epidemiology.  J Med Genet. 2006;  43 545-554
• 9 Brunner H G, van Bokhoven H. Genetic players in esophageal atresia and tracheoesophageal fistula.  Curr Opin Genet Dev. 2005;  15 314-347
• 10 Marsh A J, Wellesley D, Burge D et al. Interstitial deletion of chromosome 17 confirms a link with oesophageal atresia.  J Med Genet. 2000;  37 701-704
• 11 Kilic S S, Gurpinar A, Yakut T et al. Esophageal atresia and tracheoesophageal fistula in a patient with Digeorge syndrome.  J Pediatr Surg. 2003;  38 E21-E23
• 12 Merei J, Hasthorpe S, Farmer P et al. Visceral anomalies in prenatally adriamycin-exposed rat fetuses: a model for the VACTERL association.  Pediatr Surg Int. 1999;  15 11-16
• 13 Bishop J B, Witt K L, Sloane R A. Genetic toxicities of human teratogens.  Mutat Res. 1997;  396 9-43
• 14 Wells P G, Kim P M, Lapos R R et al. Oxidative damage in chemical teratogenesis.  Mutat Res. 1997;  396 65-78
• 15 Lipson A, Beuhler B, Bartley et al. Maternal hyperphenylalaninemia fetal effects.  J Pediatr. 1984;  104 216-220
• 16 Vogt E C. Congenital esophageal atresia.  Am J Roentgenol. 1929;  22 463-465
• 17 Ladd W E. The surgical treatment of esophageal atresia and tracheoesophageal fistulas.  N Engl J Med. 1944;  230 625-637
• 18 Gross R E. Surgery of infancy and childhood. Philadelphia: WB Saunders; 1953
• 19 Lambrecht W, Kluth D. Esophageal atresia: a new anatomic variant with gasless abdomen.  J Pediatr Surg. 1994;  29 564-565
• 20 Brantberg A, Blaas H G, Haugen S E et al. Esophageal obstruction – prenatal detection rate and outcome.  Ultrasound Obstet Gynecol. 2007;  30 180-187
• 21 Houben C H, Curry J I. Current status of prenatal diagnosis, operative management and outcome of esophageal atresia / tracheo-esophageal fistula.  Prenat Diagn. 2008;  28 667-675
• 22 Stringer M D, McKenna K M, Goldstein R B et al. Prenatal diagnosis of esophageal atresia.  J Ped Surg. 1995;  30 1258-1263
• 23 Pretorius D H, Drose J A, Dennis M A et al. Tracheooesophageal fistula in utero. Twenty-two cases.  J Ultrasound Med. 1987;  6 509-513
• 24 Kalache K D, Wauer R, Mau H et al. Prognostic significance of the pouch sign in fetuses with prenatally diagnosed esophageal atresia.  Am J Obstet Gynecol. 2000;  182 978-981
• 25 Yagel S, Sonigo P, Rousseau V et al. Esophageal atresia diagnosed with three-dimensional ultrasonography.  Ultrasound Obstet Gynecol. 2005;  26 307-308
• 26 Vijayaraghavan S B. Antenatal diagnosis of oesophageal atresia with tracheo-oesophageal fistula.  J Ultrasound Med. 1996;  15 417-419
• 27 Shulman A, Mazkereth R, Zalel Y et al. Prenatal identification of esophageal atresia: the role of ultrasonography for evaluation of functional anatomy.  Prenat Diagn. 2002;  22 669-674
• 28 Centini G, Rosignoli L, Kenanidis A et al. Prenatal diagnosis of esophageal atresia with the pouch sign.  Ultrasound Obstet Gynecol. 2003;  21 494-497
• 29 Has R, Guenay S, Topuz S. Pouch sign in prenatal diagnosis of esophageal atresia.  Ultrasound Obstet Gynecol. 2004;  23 523-524
• 30 Rokitansky A, Kolankaya A, Bichler B et al. Analysis of 309 cases of esophageal atresia for associated congenital malformations.  Am J Perinatol. 1994;  11 123-128
• 31 Chittmittrapap S, Spitz L, Kiely E M et al. Oesophageal atresia and associated anomalies.  Arch Dis Child. 1989;  64 364-368
• 32 Nicolaides K H, Snijders R JM, Cheng H H et al. Fetal gastro-intestinal and abdominal wall defects: associated malformations and chromosomal abnormalities.  Fetal Diag Ther. 1992;  7 102-115
• 33 McKenna K M, Goldstein R B, Stringer M D. Small or absent fetal stomach: prognostic significance.  Radiology. 1995;  197 729-733
• 34 Langer J C, Hussain H, Khan A et al. Prenatal diagnosis of esophageal atresia using sonography and magnetic resonance imaging.  J Pediatr Surg. 2001;  36 804-807
• 35 Matsuoka S, Takeuchi K, Yamanaka Y et al. Comparison of magnetic resonance imaging and ultrasonography in the prenatal diagnosis of congenital thoracic abnormalities.  Fetal Diagn Ther. 2003;  18 447-453
• 36 Goldberg S, Ringertz H, Barth R A. Prenatal diagnosis of horseshoe lung and esophageal atresia.  Pediatr Radiol. 2006;  36 983-986
• 37 Beasley S W. Esophageal atresia: surgical aspects. In: Stinger M, Oldham K, Mouriquand P, Howard E, Hrsg. Pediatric Surgery and Urology long-term Outcomes. Cambridge University Press, Cambridge / UK; 2006: 192–207
• 38 Spitz L, Bax N M. Esophageal atresia with and without tracheoesophageal fistula. In: Coran A, Spitz L. Operative Pediatric Surgery. London: Hodder; 2006: 109–120
• 39 Chittmittrapap S, Spitz L, Kiely et al. Anastomic leakage following surgery for esophageal atresia.  J Pediatr Surg. 1992;  27 29-32
• 40 Ghandour K E, Spitz L, Brereton R J et al. Recurrent tracheo-oesophageal fistula: experience with 24 patients.  J Paediatr Child Health. 1990;  26 89-91
• 41 Wheatley M J, Coran A G, Wesley J R. Efficacy of the Nissen fundoplication in the management of gastroesophageal reflux following esophageal atresia repair.  J Pediatr Surg. 1993;  28 53-55
• 42 Waterston D J, Carter R E, Aberdeen E. Oesophageal atresia: tracheo-oesophageal fistula. A study of survival in 218 infants.  Lancet. 1962;  I 819-822
• 43 Lopez P J, Keys C, Pierro A et al. Oesophageal atresia: improved outcome in high-risk groups?.  J Pediatr Surg. 2006;  41 331-334
• 44 Spitz L, Kiely E M, Morecroft J A et al. Oesophageal atresia: at-risk groups for the 1990s.  J Pediatr Surg. 1994;  29 723-725