Zusammenfassung
Die bildgebende Diagnostik liefert in Zusammenschau mit der klinischen Symptomatik
und der histopathologischen Untersuchung heute die wesentliche Basis zur Planung
und Nachsorge aller onkologischen Behandlungsformen. Die Sonografie, die CT und
die MRT bieten präzise morphologische Informationen als Basis für das Tumorstaging
nach dem TNM-Schema. Nuklearmedizinische Verfahren wie z. B. die PET und spezielle
MRT-Methoden erbringen zusätzliche funktionelle Informationen. Rasante Fortschritte
der Modalitäten selbst und der computergestützten Bildverarbeitung führen durch eine
stetige Verbesserung der diagnostischen Qualität zu veränderten Indikationsspektren.
Neue diagnostische Verfahren fördern und ermöglichen die Entwicklung neuer therapeutischer
Verfahren. Als Folge einer zunehmenden Integration bildgebender Diagnostik und therapeutischer
Prozeduren ist in Zukunft auch eine Veränderung klinischer Abläufe und der interdisziplinären
Zusammenarbeit zu erwarten.
Abstract
Diagnostic imaging procedures provide crucial information for pretherapeutic planning
and the follow-up of oncologic diseases. Ultrasound, CT and MRI provide detailed morphologic
information and are actually used as the gold standard for tumor staging according
to the TNM system. Nuclear medicine modalities and special MRI methods allow for
additional functional informations. Fast-paced advancements of the imaging modalities
and computerized image postprocessing tools provide important improvements of the
diagnostic quality and value. Additionally, new imaging modalities have been developed
which also support and enable the development of new therapeutic strategies. Progressive
integration of diagnostic imaging and therapeutic procedures will presumably also
have an impact on traditional clinical workflows and interdisciplinary cooperation.
Schlüsselwörter
onkologische Diagnostik - Untersuchungsmethoden - bildgestützte Behandlung
Key words
oncologic diagnosis - diagnostic methods - image guided therapy
Literatur
- 1
Huppert P E, Lauchart W, Duda S H et al.
Chemoembolisation des hepatozellularen Karzinoms: Welche Faktoren bestimmen Therapieansprechen
und Überleben?.
RöFo Fortschr Röntgenstr.
2004;
176
375-385
- 2
Hoffmann R T, Jakobs T F, Muacevic A et al.
Interventionelle Onkologie bei Lungentumoren.
Radiologe.
2007;
47
1109-1116
- 3
Pereira P L.
Actual role of radiofrequency ablation of liver metastases.
Eur Radiol.
2007;
17
2062-2070
- 4
König C W, Trübenbach J, Fritz J et al.
Contrast enhanced MR-guided biopsy of hepatocellular carcinoma.
Abdom Imaging.
2004;
29
71-76
- 5
Hashizume M.
MRI-guided laparoscopic and robotic surgery for malignancies.
Int J Clin Oncol.
2007;
12
94-98
- 6
Kuhl C K, Schrading S, Bieling H B et al.
MRI for diagnosis of pure ductal carcinoma in situ: a prospective observational study.
Lancet.
2007;
370
485-492
- 7
Schulz-Wendtland R, Hermann K P, Wacker T et al.
Aktueller Stand und weitere Perspektiven der digitalen Mammographie.
Radiologe.
2008;
48
324-334
- 8
Fan Z H, Chen M H, Dai Y et al.
Evaluation of primary malignancies of the liver using contrast-enhanced sonography:
correlation with pathology.
AJR Am J Roentgenol.
2006;
186
1512-1519
- 9
Wu W, Chen M H, Yin S S et al.
The role of contrast-enhanced sonography of focal liver lesions before percutaneous
biopsy.
AJR Am J Roentgenol.
2006;
187
752-761
- 10
Horger M, Kanz L, Denecke B et al.
The benefit of using whole-body, low-dose, nonenhanced, multidetector computed tomography
for follow-up and therapy response monitoring in patients with multiple myeloma.
Cancer.
2007;
109
1617-1626
- 11
McFarland E G, Levin B, Lieberman D A et al.
Revised colorectal screening guidelines: joint effort of the American Cancer Society,
U.S. Multisociety Task Force on Colorectal Cancer, and American College of Radiology.
Radiology.
2008;
248
717-720
- 12
Bellomi M, Petralia G, Sonzogni A et al.
CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy
in rectal carcinoma: initial experience.
Radiology.
2007;
244
486-493
- 13
Grenacher L, Thorn M, Knaebel H P et al.
Bedeutung der 3-D-Bildgebung und computerbasierten Nachverarbeitung fur die Chirurgie
der Leber und des Pankreas.
RöFo Fortschr Röntgenstr.
2005;
177
1219-1226
- 14
Salah Z, Kastner M, Dammann F et al.
Pre-operative planning of a complete mastoidectomy: Semi-automatic segmentation and
evaluation.
JCARS.
2006;
1
213-222
- 15
Dammann F, Hoffmann J, Horger M et al.
Rational diagnosis of squamous cell carcinoma in the head and neck region: Comparative
evaluation of CT, MRI, and 18FDG-PET.
AJR Am J Roentgenol.
2004;
184
1326-1331
- 16
Wersebe A, Wiskirchen J, Decker U et al.
Comparison of Gadolinium-BOPTA and Ferucarbotran-enhanced three-dimensional T1-weighted dynamic liver magnetic resonance imaging in the same patient.
Invest Radiol.
2006;
41
264-271
- 17
Yamada I, Okabe S, Enomoto M et al.
Colorectal carcinoma: in vitro evaluation with high-spatial-resolution 3D-constructive
interference in steady-state MR imaging.
Radiology.
2008;
246
444-453
- 18
Kwee T C, Takahara T, Ochiai R et al.
Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS):
features and potential applications in oncology.
Eur Radiol.
2008;
18
1937-1952
- 19
Schaefer J F, Schlemmer H P.
Total-body MR-imaging in oncology.
Eur Radiol.
2006;
16
2000-2015
- 20
Giesel F L, Wüstenberg T, Bongers A et al.
MR-basierte Methoden der funktionellen Bildgebung des zentralen Nervensystems.
RöFo Fortschr Röntgenstr.
2005;
177
714-730
- 21
Chang J, Thakur S B, Huang W et al.
Magnetic resonance spectroscopy imaging (MRSI) and brain functional magnetic resonance
imaging (fMRI) for radiotherapy treatment planning of glioma.
Technol Cancer Res Treat.
2008;
7
349-362
- 22
Hamstra D A, Rehemtulla A, Ross B D.
Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology.
J Clin Oncol.
2007;
25
4104-4109
- 23
Koh D M, Collins D J.
Diffusion-weighted MRI in the body: applications and challenges in oncology.
AJR Am J Roentgenol.
2007;
188
1622-1635
- 24
Robbins E.
Radiation risks from imaging studies in children with cancer.
Pediatr Blood Cancer.
2008;
51
453-457
- 25
Schenk J P, Graf N, Gunther P et al.
Role of MRI in the management of patients with nephroblastoma.
Eur Radiol.
2008;
18
683-691
- 26
Hwang S, Panicek D M.
Magnetic resonance imaging of bone marrow in oncology, Part 1.
Skeletal Radiol.
2007;
36
913-920
- 27
Frericks B B, Meyer B C, Martus P et al.
MRI of the thorax during whole-body MRI: evaluation of different MR sequences and
comparison to thoracic multidetector computed tomography (MDCT).
J Magn Reson Imaging.
2008;
27
538-545
- 28
Hwang S, Panicek D M.
Magnetic resonance imaging of bone marrow in oncology, Part 2.
Skeletal Radiol.
2007;
36
1017-1027
- 29
Sharma N, Neumann D, Macklis R.
The impact of functional imaging on radiation medicine.
Radiat Oncol.
2008;
3
25
- 30
Antoch G, Bockisch A.
Combined PET / MRI: a new dimension in whole-body oncology imaging?.
Eur J Nucl Med Mol Imaging.
2008;
, [Epub ahead of print]
- 31 Perry N et al. European guidelines for quality assurance in breast cancer screening
and diagnosis. 4th edition. European Communities 2006
- 32
Frerich B, Forster M, Schiefke F et al.
Sentinel lymph node biopsy in squamous cell carcinomas of the lips and the oral cavity
– a single center experience.
J Surg Oncol.
2007;
95
97-105
- 33
Cademartiri F, Luccichenti G, Maffei E et al.
Imaging for oncologic staging and follow-up: review of current methods and novel approaches.
Acta Biomed.
2008;
79
85-91
- 34
Heussel C P, Meier S, Wittelsberger S et al.
Quantitative CT-Verlaufskontrolle von Lebermalignomen nach RECIST und WHO im Vergleich
zur Volumetrie.
RöFo Fortschr Röntgenstr.
2007;
179
958-964
- 35
Mackie T R, Tome W.
Advanced image-guided external beam radiotherapy.
Cancer Treat Res.
2008;
139
7-39
- 36
Kwek J W, Iyer R B, Dunnington J et al.
Spectrum of imaging findings in the abdomen after radiotherapy.
AJR Am J Roentgenol.
2006;
187
1204-1211
Prof. Dr. F. Dammann
Radiologisches Zentralinstitut · Klinik am Eichert
Eichertstr. 3
73035 Göppingen
Telefon: 0 71 61 / 64 20 15
eMail: florian.dammann@kae.de