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Planta Med 2008; 74(15): 1774-1778
DOI: 10.1055/s-0028-1088336
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Myristica malabarica Heals Stomach Ulceration by Increasing Prostaglandin Synthesis and Angiogenesis

Biswanath Maity1 , Debashish Banerjee1 , Sandip K. Bandyopadhyay1 , Subrata Chattopadhyay2
  • 1Department of Biochemistry, Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences & IPGME&R, Kolkata, India
  • 2Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India
Further Information

Publication History

Received: March 31, 2008 Revised: August 23, 2008

Accepted: September 3, 2008

Publication Date:
18 November 2008 (online)

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Abstract

Earlier we had shown that on the 3rd day of its administration to mice, indomethacin (18 mg kg−1, p. o.) produced maximum stomach ulceration with a damage score of 3.46, which was reduced by a 3-day treatment with the methanol extract of Myristica malabarica (40 mg kg−1, p. o.) and omeprazole (3 mg kg−1, p. o.) to 0.95 and 0.82, respectively. Presently, we investigated the possible role of the test samples in modulating PG synthesis and angiogenesis for their healing action. The ulceration was found to be associated with suppression of PGE2, VEGF and vWF VIII, and an increase in EGF and endostatin levels. Treatment with the plant extract reversed all these parameters accounting for its healing activity. However, despite providing similar healing, omeprazole did not alter these parameters.

Abbreviations

EGF:epidermal growth factor

PG:prostaglandin

BEGF:vascular endothelial growth factor

vWF:von Willebrand factor

K:kinetin

AS:adenine sulfate

Key words

Myristica malabarica - Myristicaceae - gastrointestinal ulceration - angiogenesis - PGE2

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Dr. Subrata Chattopadhyay

Bio-Organic Division

Bhabha Atomic Research Centre

Mumbai – 400 085

India

Phone: +91-22-2559-3703

Fax: +91-22-2550-5151

Email: schatt@barc.gov.in

    www.thieme-connect.de/ejournals/toc/plantamedica