Planta Med 2008; 74(15): 1828-1831
DOI: 10.1055/s-0028-1088335
Letter
Natural Products Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Demethoxycurcumin and its Semisynthetic Analogues as Antitubercular Agents

Dinesh Kumar Agrawal1 , Dharmendra Saikia2 , Richa Tiwari2 , Shweta Ojha2 , Karuna Shanker1 , Jonnala Kotesh Kumar1 , Anil Kumar Gupta2 , Sudeep Tandon3 , Arvind Singh Negi1 , Suman Preet Singh Khanuja2
  • 1Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India
  • 2Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India
  • 3Process Division, Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR), Lucknow, India
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Publikationsverlauf

Received: April 24, 2008 Revised: August 28, 2008

Accepted: August 31, 2008

Publikationsdatum:
07. November 2008 (online)

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Abstract

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H37Rv strain at 200 μg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 μg/mL.

Abbreviations

H37Rv:Mycobacterium tuberculosis H37Rv strain

MIC:minimum inhibitory concentration

References

Dr. Arvind Singh Negi

Analytical Chemistry Division

Central Institute of Medicinal and Aromatic Plants (CIMAP-CSIR)

Kukrail Picnic Spot Road

P. O. CIMAP

Lucknow – 226015

India

Telefon: +91-522-2342676, Ext. 327

Fax: +91-522-2342666

eMail: arvindcimap@rediffmail.com