Chiral Recognition in Biomembrane
Models: What is behind a ‘Simple Model’

Stefano Borocci; Francesca Ceccacci; Oscar Cruciani; Giovanna Mancini; Alessandro Sorrenti

doi:10.1055/s-0028-1088148

ACCOUNT

Chiral Recognition in Biomembrane Models: What is behind a ‘Simple Model’

Stefano Borocci^a, Francesca Ceccacci^b, Oscar Cruciani^c, Giovanna Mancini*^c, Alessandro Sorrenti^c
^a Dipartimento di Scienze Ambientali, Università della Tuscia, Largo dell’Università, 01100 Viterbo, Italy
^b Dipartimento di Chimica, Università degli Studi di Roma ‘La Sapienza’, P. le Aldo Moro 5, 00185 Roma, Italy
^c CNR, Istituto di Metodologie Chimiche, Dipartimento di Chimica, Università degli Studi di Roma ‘La Sapienza’, P. le Aldo Moro 5, 00185 Roma, Italy
Fax: +39(06)490421; e-Mail: giovanna.mancini@uniroma1.it;

Abstract

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Abstract

The investigation of chiral recognition in micelles and liposomes used as biomembrane models relies, in principle, on physicochemical tools, such as circular dichroism, NMR spectroscopy, and theoretical calculations. However, the need for proper model aggregates and suitable markers of chirality has prompted us to face some organic synthesis exercises with problems that synthetic chemists usually find with much more complex syntheses. Our synthetic efforts were compensated by the results we got in the successive physicochemical investigations.

1 Introduction

2 The Chirality Markers

3 The Amphiphilic Components and the Models

4 The Tools: Some Brief Remarks

5 After All the Work: The Results

6 Concluding Remarks

Key words

chiral recognition - deracemization - aggregates - amphiphiles - chirality markers

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