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Synfacts 2009(2): 0131-0131  
DOI: 10.1055/s-0028-1087609
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of RK-397

Contributor(s): Philip Kocienski, Zofia Komsta
H. Guo, M. S. Mortensen, G. A. O’Doherty*
West Virginia University, Morgantown, USA
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Publication History

Publication Date:
22 January 2009 (online)

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Significance

RK-397 is an antibiotic isolated from a Japanese soil bacterium. It showed some antifungal and antibacterial activity along with ­cytotoxic properties towards certain human leukemia cells (50 mg/mL activity). For a total synthesis of RK-397 see: S. E. Denmark, S. Fujimori J. Am. Chem. Soc. 2005, 127, 8971.