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Synfacts 2008(11): 1134-1134  
DOI: 10.1055/s-0028-1083416
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ()-Platencin

Contributor(s): Philip Kocienski, Indu Dager
J. Hayashida, V. H. Rawal*
the University of Chicago, USA
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Publication History

Publication Date:
23 October 2008 (online)

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Significance

Platencin is isolated from Streptomycis platensis MA7339. Platencin combats methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci and Streptococcus pneumoniae. Platencin structurally resembles platensimycin and inhibits the fatty acids synthesis pathway in bacteria by binding with the initiation- condensing and elongation-condensing enzymes FabH and FabF/B.