Progressive Bilateral Localised Amyloidosis of the Eyelids and Conjunctiva Four Years after MALT Lymphoma: A Case Report

Introduction

Amyloidosis refers to a heterogeneous group of disorders characterized by the deposition of insoluble protein fibrils in various tissues, including the eyes and their adnexa. It can occur either systemically or locally and is classified based on the type of amyloid protein involved. To date, 42 different amyloid fibril proteins have been identified; however, not all are associated with ocular deposition [1].

Orbital and adnexal amyloidosis is rare and most commonly affects the eyelid, orbit, and conjunctiva. While it can be the initial manifestation of systemic involvement, most cases are localized with amyloid light-chain (AL) deposits being the most common, resulting from the accumulation of misfolded immunoglobulin light chains [2], [3]. Due to the heterogeneity of the disease and the limited literature available, the diagnosis and management of orbital and adnexal amyloidosis remain challenging.

Publication History

Received: 06 October 2025

Accepted: 02 December 2025

Article published online:
04 February 2026

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