Evaluation of Serum Uric Acid Levels in Pediatric Migraine Patients

Abstract

Objective

This study examined serum uric acid levels in children with migraine compared to healthy controls, and explored links with gender and attack frequency.

Methods

A retrospective analysis was conducted on pediatric migraine patients and controls seen between August 2019 and January 2025. Uric acid, Hb, Hct, iron, and TIBC levels were recorded.

Results

No significant difference in uric acid levels was found between groups or by attack frequency. However, male patients had higher uric acid levels than females (p=0.046). Other blood parameters were similar.

Conclusion

Uric acid is not a reliable standalone marker for pediatric migraine, though gender differences suggest potential hormonal influences. Further research is needed.

Zusammenfassung

Ziel

Diese Studie untersuchte Serum-Harnsäurewerte bei Kindern mit Migräne im Vergleich zu gesunden Kontrollen sowie Zusammenhänge mit Geschlecht und Anfallshäufigkeit.

Methoden

Daten von Patienten zwischen August 2019 und Januar 2025 wurden retrospektiv ausgewertet. U.a. wurden Harnsäure-, Hb-, Hct-, Eisen- und TIBC-Werte erfasst.

Ergebnisse

Es gab keinen signifikanten Unterschied der Harnsäurewerte zwischen den Gruppen oder zur Anfallshäufigkeit. Jungen zeigten jedoch höhere Werte als Mädchen (p=0,046). Andere Blutwerte waren vergleichbar.

Schlussfolgerung

Harnsäure allein scheint kein verlässlicher Marker für Migräne bei Kindern zu sein. Der Geschlechtsunterschied könnte auf hormonelle Einflüsse hinweisen. Weitere Studien sind nötig.

Keywords

Migraine - Children - Uric acid - Level

Schlüsselwörter

Migräne - Kinder - Harnsäure - Niveau

Publication History

Received: 01 June 2025

Accepted after revision: 14 August 2025

Article published online:
26 September 2025

• References

• 1 Buse DC, Reed ML, Fanning KM. et al. Demographics, headache features, and comorbidity profiles in relation to headache frequency in people with migraine: results of the American Migraine Prevalence and Prevention (AMPP) study. Headache 2020;
• 2 Dodick DW. Migraine. Lancet 2018; 391: 1315-1330
• 3 Jhonson K. BH. Neurogenic inflammatory mechanisms in migraine. In: Olesen J, Ramadan N, Tfelt-Hansen P, Welch KA, editors. The Headaches. 3^rd ed.. Lippincott Williams & Wilkins; 2006. 309-319
• 4 Basaga HS. Biochemical aspects of free radicals. Biochem Cell Biol 1990; 68: 989-998
• 5 Peng F, Zhang B, Zhong X. et al. Serum uric acid levels of patients with multiple sclerosis and other neurological diseases. Mult Scler 2008; 14: 188-196
• 6 Hooper DC, Spitsin S, Kean RB. et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc Natl Acad Sci U S A 1998; 95: 675-680
• 7 Hooper DC, Scott GS, Zborek A. et al. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J 2000; 14: 691-698
• 8 Kastenbauer S, Koedel U, Pfister HW. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. J Infect Dis 1999; 180: 1164-1170
• 9 Weir CJ, Muir SW, Walters MR. et al. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke 2003; 34: 1951-1956
• 10 Gupta R, Pathak R, Bhatia MS. et al. Comparison of oxidative stress among migraineurs, tension-type headache subjects, and a control group.
• 11 Yilmaz G, Surer H, Inan LE. et al. Increased nitrosative and oxidative stress in platelets of migraine patients. Tohoku J Exp Med 2007; 211: 23-30
• 12 Magis D, Ambrosini A, Sandor P. et al. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache 2007; 47: 52-57
• 13 D'Amico D, Ferraris A, Leone M. et al. Increased plasma nitrites in migraine and cluster headache patients in interictal period: basal hyperactivity of L-arginine-NO pathway?. Cephalalgia 2002; 22: 33-36
• 14 Dodick DW. A phase-by-phase review of migraine pathophysiology. Headache 2018; 58: 4-16
• 15 Erdener SE, Kaya Z, Dalkara T. Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine. J Headache Pain 2021; 22: 138
• 16 Yazar HO, Yazar T, Aygun A. et al. Evaluation of simple inflammatory blood parameters in patients with migraine. Ir J Med Sci 2020; 189: 677-683
• 17 Xie KH, Liu LL, Su CY. et al. Low antioxidant status of serum uric acid, bilirubin, albumin, and creatinine in patients with benign paroxysmal positional vertigo. Front Neurol 2020; 11: 601695
• 18 Suzuki T. Nitrosation of uric acid induced by nitric oxide under aerobic conditions. Nitric Oxide 2007; 16: 266-273
• 19 Zharikov S, Krotova K, Hu H. et al. Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol 2008; 295: C1183-C1190
• 20 Altunkaynak Y, Keskek A, Donmezler S. et al. A study of the relationship between serum uric acid levels and pain in patients with migraine. Medicine (Baltimore) 2023; 102: e32810
• 21 Yang Z, Xu P, Geng C. et al. Evaluation of simple antioxidant blood parameters in patients with migraine. Front Neurol 2022; 13: 939363
• 22 Brody DM, Litvan I, Warner S. et al. Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord 2016; 31: 663-667
• 23 Erdal N, Altunkaynak E, Öztürk M. et al. Evaluation of lipid peroxidation representing oxidative stress in patients with migraine. Dusunen Adam J Psychiatry Neurol Sci 2005; 18: 129-135
• 24 Maynard JW, McAdams-DeMarco MA, Law A. et al. Racial differences in gout incidence in a population-based cohort: Atherosclerosis Risk in Communities Study. Am J Epidemiol 2014; 179: 576-583
• 25 Wakasugi M, Kazama JJ, Narita I. et al. Association between hypouricemia and reduced kidney function: a cross-sectional population-based study in Japan. Am J Nephrol 2015; 41: 138-146
• 26 Kuwabara M, Niwa K, Ohtahara A. et al. Prevalence and complications of hypouricemia in a general population: a large-scale cross-sectional study in Japan. PLoS One 2017; 12: e0176055
• 27 Wilcox WD. Abnormal serum uric acid levels in children. J Pediatr 1996; 128: 731-741
• 28 Oyama C, Takahashi T, Oyamada M. et al. Serum uric acid as an obesity-related indicator in early adolescence. Tohoku J Exp Med 2006; 209: 257-262
• 29 Shatat IF, Abdallah RT, Sas DJ. et al. Serum uric acid in U.S. adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors. Pediatr Res 2012; 72: 95-100