Subscribe to RSS
DOI: 10.1055/a-2683-6349
Acute peripartum pontine ischemic stroke during epidural analgesia

Abstract
We report a rare case of peripartum pontine stroke in a 34-year-old primipara initially attributed to an episode of severe transient hypotension caused by the subdural spread of local anesthetic during epidural analgesia for delivery. The rapid intrapartum intervention by the obstetric team because of spinal shock clinical pictures and fetal bradycardia using high vacuum extraction prevented the risk of fetal ischemic-hypoxic damage. A healthy child was born with an Apgar score of 8/10, 3790 grams /53 cm, with a normal neonatal course. On the third postpartum day, because of persistent neurologic symptoms (headache, urinary, and fecal incontinence), brain magnetic resonance imaging indicated a pontine ischemic lesion. The symptoms gradually regressed with acetylsalicylic acid and physical therapy, and on the 17th day, the patient was discharged home. After puerperium and recovery, thrombophilia were detected. The case indicates the importance of rapid intervention by the obstetric team in case of sudden peripartum maternal and fetal complications.
Publication History
Received: 05 May 2025
Accepted after revision: 31 July 2025
Article published online:
01 September 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
References
- 1 James AH, Bushnell CD, Jamison MG. et al. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol 2005; 106: 509-516
- 2 Wildman JK, Rimawi BH. Cerebral pontine infarctions during pregnancy – A case report and review of the literature. Case Rep Womens Health 2019; 21: e00097
- 3 Croles FN, Nasserinejad K, Duvekot JJ. et al. Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and Bayesian meta-analysis. BMJ 2017; 359: j4452
- 4 Mehta M, Salmon N. Extradural block. Confirmation of the injection site by X-ray monitoring. Anaesthesia 1985; 40: 1009-1025
- 5 Jenkins JG. Some immediate serious complications of obstetric epidural analgesia and anaesthesia: a prospective study of 145,550 epidurals. Int J Obstet Anesth 2005; 14: 37-42
- 6 Agarwal D, Mohta M, Tyagi A. et al. Subdural block and the anaesthetist. Anaesth Intens Care 2010; 38: 20-26
- 7 Smith GB, Barton FL, Watt JH. Extensive spread of local anaesthetic solution following subdural insertion of an epidural catheter during labour. Anaesthesia 1984; 39: 355-358
- 8 Kumral E, Bayülkem G, Evyapan D. Clinical spectrum of pontine infarction. Clinical-MRI correlations. J Neurol 2002; 249: 1659-1670
- 9 Simone B, De Stefano V, Leoncini E. et al. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetetrahydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol 2013; 28: 621-647
- 10 Gerhardt A, Scharf RE, Beckmann MW. et al. Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med 2000; 342: 374-380