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Synfacts 2025; 21(10): 1043
DOI: 10.1055/a-2680-9502
Organo- and Biocatalysis

Chiral-Pyridoxal-Catalyzed Biomimetic Aldol Reaction of Glycinate with Aldehydes

Authors

Liang H, Ren P, Wang L, Cai D, Gong S, Liu S, Xiao X *, Ding K, Zhao B *. Shanghai Normal University and Shanghai Jiao Tong University, P. R. China
Asymmetric Biomimetic Aldol Reaction of Glycinate Enables Highly Efficient Synthesis of Chiral β-Hydroxy-α-Amino Acid Derivatives.

Nat. Catal. 2025;
8: 668-677
DOI: 10.1038/s41929-025-01364-z
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Keywords

chiral pyridoxal - biomimetic aldol reaction - glycinate - β-hydroxy-α-amino acid

Significance

Zhao, Xiao, and co-workers report a broadly applicable strategy using a chiral pyridoxal catalyst to promote highly efficient and stereoselective biomimetic aldol reactions across a wide substrate scope. Using a high-throughput asymmetric synthesis platform has enabled the generation of over 1,700 diverse β-hydroxy-α-amino acid derivatives, offering a valuable chiral library for drug discovery.


 

Comment

This work represents an advancement in biomimetic catalysis through the development of chiral pyridoxal catalysts for the aldol reaction between glycinate and aldehydes. Moreover, the success of these pyridoxal-based catalysts greatly expands the chemical repertoire of vitamin B6 mimetic systems, providing new insights into the catalytic mechanisms of PLP (pyridoxal 5′-phosphate)-dependent enzymes.


 

 

Publication History

Article published online:
23 September 2025

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