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Int J Angiol
DOI: 10.1055/a-2624-5607
Review Article

The History of Coronary Artery Disease

Andrew J. Gorton 
1   Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky
,
Sibu P. Saha
1   Division of Cardiothoracic Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky
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Abstract

Coronary artery disease (CAD) is the leading cause of mortality worldwide and although often considered a modern disease its origins trace back to ancient civilizations. This historical review explores the evolution of understanding, diagnosis, and treatment of CAD. It will discuss early evidence of atherosclerosis in mummies through pioneers in the field of medical and surgical understanding to innovative surgical and interventional advances in the modern era. The progression of medical therapies, including the discovery and utilization of digitalis, nitrates, aspirin, beta blockers, and statins, is discussed alongside the evolution of catheter-based and surgical interventions such as percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Future therapies will be briefly discussed. Despite remarkable progress, CAD remains a major public health challenge, emphasizing the importance of continued innovation in prevention, diagnosis, and treatment. Understanding the historical trajectory of CAD provides critical insights for shaping the future of cardiovascular medicine.

Keywords

coronary artery disease - angina pectoris - coronary angiography - percutaneous coronary intervention - coronary artery bypass grafting


Publication History

Article published online:
27 June 2025

© 2025. International College of Angiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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