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Semin Thromb Hemost
DOI: 10.1055/a-2619-2485
Review Article

Coagulation Abnormalities Associated with COVID-19: A Narrative Review

Massimo Franchini
1   Department of Transfusion Medicine and Hematology, Carlo Poma Hospital, Mantua, Italy
,
Daniele Focosi
2   North-Western Tuscany Blood Bank, Pisa University Hospital, Pisa, Italy
,
Pier Mannuccio Mannucci
3   Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico and University of Milan, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy
› Author Affiliations
Funding P.M.M. was partially supported by the Italian Ministry of Health – Bando Ricerca Corrente 2024.
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Abstract

Coronavirus disease 2019 (COVID-19), a viral respiratory illness caused by severe acute respiratory disease coronavirus 2 (SARS-COV-2), has caused in the last 5 years a global pandemic of unprecedented scale in the modern era. Other than the typical respiratory symptoms, patients suffering from moderate to severe COVID-19 are at risk of developing a peculiar systemic coagulopathy, known as COVID-19-associated coagulopathy. In addition to a predominantly hypercoagulable state, COVID-19 patients may experience hemorrhagic complications triggered by the viral infection. The current knowledge on the underlying molecular mechanisms, the laboratory and clinical characteristics of coagulation abnormalities associated with COVID-19, along with their management, will be summarized in this narrative review.

Keywords

COVID-19 - SARS-CoV-2 - coagulopathy - thrombosis - bleeding

Authors' Contributions

M.F. and D.F. wrote the article. P.M.M. revised the article.




Publication History

Received: 12 March 2025

Accepted: 19 May 2025

Accepted Manuscript online:
23 May 2025

Article published online:
17 June 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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