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Horm Metab Res 2025; 57(05): 303-314
DOI: 10.1055/a-2604-4177
Review

Thyroid Gland and Pregnancy – Clinical Update

Violeta Mladenovic
1   Clinic for Endocrinology, Diabetes and Metabolic Diseases, University of Kragujevac, Kragujevac, Serbia (Ringgold ID: RIN127740)
,
Ravi Shah 
2   Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Ringgold ID: RIN29751)
,
Sanja Medenica
3   Department of Endocrinology, Internal Medicine Clinic, Clinical Center of Montenegro, Podgorica, Montenegro
,
Pinaki Dutta
2   Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Ringgold ID: RIN29751)
,
Nikola Zankovic
4   Faculty of Medicine, University of Montenegro, Podgorica, Montenegro (Ringgold ID: RIN187153)
,
Slavica Aksam
5   Clinic for Gynecology and Obstetrics, University of Belgrade, Belgrade, Serbia
,
Jayaditya Ghosh
2   Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Ringgold ID: RIN29751)
,
MdSadam Hussain
2   Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India (Ringgold ID: RIN29751)
,
Zoran Gluvic
6   Endocrinology, University of Belgrade, Belgrad, Serbia (Ringgold ID: RIN54801)
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Abstract

Thyroid function undergoes significant alterations during pregnancy due to changes in hormone levels and higher metabolic demands. The thyroid gland in pregnancy enlarges by 10%; however, in iodine-deficient areas, this growth might reach 40%. Elevated levels of human chorionic gonadotropin (hCG) in early pregnancy leads to increased thyroid hormone production. While triiodothyronine (T3) and thyroid-stimulating hormone (TSH) do not cross the placenta, thyroxine (T4) does. Thyroid hormone demands peaks between weeks 16 and 20 of pregnancy and remains high until delivery. There is a rise in the levels of thyroxine-binding globulin (TBG), during the period of pregnancy, raising total T4 and T3 levels while TSH levels usually decrease. Pregnancy-related thyroid disorders, such as hypothyroidism, hyperthyroidism, and autoimmune thyroid diseases (AITD), carry the potential to impair the well-being of both the child as well as the mother. A range of 5–20% of women belonging to the reproductive age group have AITD, which can be associated with the possibility of infertility, miscarriages, and/or poor pregnancy outcomes. If improperly managed, overt hypothyroidism can cause severe complications such as developmental delay and preeclampsia. Effective management requires regular monitoring and appropriate treatment adjustment. Treatment for hypothyroidism involves levothyroxine, whereas cautious use of antithyroid medications is advised for hyperthyroidism. Postpartum thyroiditis (PPT), an autoimmune condition occurring after childbirth, requires careful management to address both hyperthyroid and hypothyroid phases. A comprehensive understanding and management of these conditions are critical for optimizing maternal and fetal health outcomes. Thyroid disorders are common in women of reproductive age group.

Keywords

thyroid gland - pregnancy - autoimmune thyroid diseases - hypothyroidism - post-partum thyroiditis


Publication History

Received: 25 September 2024

Accepted after revision: 04 May 2025

Article published online:
03 June 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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