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DOI: 10.1055/a-2593-9749
Neuroimaging and Metabolic Features of Optic Pathway Glioma in a Child with Neurofibromatosis Type 1: Low-Grade Glioma Transformation in the Left Optic Radiation
Neuroimaging und metabolische Merkmale des Sehbahnglioms bei einem Kind mit Neurofibromatose Typ 1: Niedriggradige Gliomtransformation in der linken Sehbahnstrahlung
Introduction
Neurofibromatosis type 1 (NF1) is the most common single-gene genetic disorder, affecting 1/3500 children [1]. The NF-1 gene responsible for the disease is located on the length of chromosome 17 [2] [3]. NF-1 affects various organ systems, including the skin, nervous, endocrine, eye, and skeleton [2] [3]. Patients with NF-1 have a high predisposition to develop both benign and malignant tumors, including optic pathway gliomas (OPG), which are seen in 15–20% of NF-1 patients. Optic gliomas (OPG) represent 1–2% of all brain tumors, with most being benign and associated with NF-1 [1] [4] [5].
Publication History
Received: 04 October 2024
Accepted after revision: 23 April 2025
Article published online:
28 May 2025
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