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Synfacts 2025; 21(06): 645
DOI: 10.1055/a-2588-2818
DOI: 10.1055/a-2588-2818
Peptide Chemistry
Total Synthesis of Tetraselide via Liquid-Phase Peptide Synthesis Using Soluble Hydrophobic Tags
Autoren
Nakahara H,
Sennari G,
Azami H,
Tsutsumi H,
Watanabe Y,
Noguchi Y,
Inahashi Y,
Iwatsuki M,
Hirose T *,
Sunazuka T *.
Kitasato University, Tokyo, Japan
Isolation, Total Synthesis and Structure Determination of Antifungal Macrocyclic Depsipeptide, Tetraselide.
Chem. Sci. 2025;
16: 6060-6069
DOI: 10.1039/D5SC00566C
Isolation, Total Synthesis and Structure Determination of Antifungal Macrocyclic Depsipeptide, Tetraselide.
Chem. Sci. 2025;
16: 6060-6069
DOI: 10.1039/D5SC00566C
Keywords
cyclic peptides - macrocyclization - serine/threonine ligation - tetraselide - hydrophobic tag - liquid-phase peptide synthesis
Significance
Cyclic peptides are essential in medicinal chemistry. The authors present the total synthesis and structural determination of tetraselide via liquid-phase peptide synthesis (LPPS) using two tag carrier molecules.
Comment
This novel synthetic process employed an LPPS method and utilized a TCbz group for
the one-pot synthesis of four serine fragments. The coupling of peptide fragments
is achieved through a serine/threonine ligation (STL) reaction.
Publikationsverlauf
Artikel online veröffentlicht:
22. Mai 2025
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