Synfacts 2025; 21(06): 645
DOI: 10.1055/a-2588-2818
Peptide Chemistry

Total Synthesis of Tetraselide via Liquid-Phase Peptide Synthesis Using Soluble Hydrophobic Tags

Rezensent(en):
Hisashi Yamamoto
,
Nakahara H, Sennari G, Azami H, Tsutsumi H, Watanabe Y, Noguchi Y, Inahashi Y, Iwatsuki M, Hirose T *, Sunazuka T *. Kitasato University, Tokyo, Japan
Isolation, Total Synthesis and Structure Determination of Antifungal Macrocyclic Depsipeptide, Tetraselide.

Chem. Sci. 2025;
16: 6060-6069
DOI: 10.1039/D5SC00566C
 

Significance

Cyclic peptides are essential in medicinal chemistry. The authors present the total synthesis and structural determination of tetraselide via liquid-phase peptide synthesis (LPPS) using two tag carrier molecules.


Comment

This novel synthetic process employed an LPPS method and utilized a TCbz group for the one-pot synthesis of four serine fragments. The coupling of peptide fragments is achieved through a serine/threonine ligation (STL) reaction.




Publikationsverlauf

Artikel online veröffentlicht:
22. Mai 2025

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