Broadening Arene C–H Alkylations via Radical−Radical Cross-Coupling

Keywords

photocatalysis - arene C−H alkylation - radical cross-coupling - NHC catalysis

Significance

This work introduces a powerful and general strategy for late-stage C(sp ²)−H alkylation via selective coupling of differently hybridized radical species, enabling modular scaffold diversification using simple acids and alcohols. It overcomes key limitations of traditional methods and expands access to complex chemical space.

Comment

A sequential radical–radical cross-coupling strategy enables late-stage orthogonal functionalization of drug scaffolds with precision. Leveraging dynamic orbital selection, this method expands chemical space and streamlines the synthesis of complex bioactive molecules.

Publication History

Article published online:
22 May 2025