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Semin Thromb Hemost
DOI: 10.1055/a-2576-4895
Original Article

Risk Factors of Catheter-Related Thrombosis in Elderly Patients with Lung Cancer Based on Thromboelastography: A Retrospective, Case-Control Study

Jiaji Hu
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Binbin Xu
3   School of Nursing, Hunan University of Chinese Medicine, Changsha, Hunan Province, People's Republic of China
,
Nian Yao
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Sha Peng
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Jiaxin Lv
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Haixia Yu
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Jianmei Hou
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
,
Zhengkun Shi
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
,
Jianan Wang
4   Vascular Access Department, Hainan Provincial People's Hospital, Hainan Province, People's Republic of China
,
Xin Huang
5   Department of Nursing, Affiliated Hospital of Qinghai University, Qinghai, People's Republic of China
,
Guiyuan Ma
2   Xiangya School of Nursing, Central South University, Changsha, People's Republic of China
,
Jinghui Zhang 
1   Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, People's Republic of China
6   National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China
› Author Affiliations
Funding This study was supported by the National Natural Science Foundation of China (grant number: 72174210), Hunan Nursing Society Project (grant number: HNKY202303), and Hunan Provincial Natural Science Foundation joint Project (grant number: 2022JJ70168).
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Abstract

Catheter-related thrombosis (CRT) poses serious risks for cancer patients. Identifying risk factors and implementing targeted interventions can prevent CRT. To explore thromboelastogram parameters and clinical risk factors for CRT in elderly lung cancer patients. A total of 663 elderly lung cancer patients were selected from three hospitals in Hunan, Hainan, and Qinghai provinces in China from January 1, 2022, to June 30, 2024. The patients were divided into two groups: a CRT group (221 patients) and a non-CRT group (442 patients), with a ratio of 1:2. A between-group comparison and binary logistic regression were used to analyze risk factors for CRT in elderly lung cancer patients. Binary logistic regression analysis showed that decreased R (odds ratio [OR]: 0.849, 95% confidence interval [CI]: 0.763–0.945, p = 0.003), decreased K (0.571, 95% CI: 0.404–0.807, p = 0.001), advanced age (OR: 1.073, 95% CI: 1.033–1.113, p < 0.001), elevated platelet count (OR: 1.006, 95% CI: 1.004–1.009, p < 0.001), increased hemoglobin level (OR: 1.020, 95% CI: 1.009–1.031, p < 0.001), shortened PT (OR: 0.904, 95% CI: 0.830–0.985, p = 0.022), surgery ≤ 1 month (OR: 2.258, 95% CI: 1.420–3.590, p = 0.001), male sex (OR: 4.534, 95% CI: 2.815–7.304, p < 0.001), diabetes (OR: 2.478, 95% CI: 1.373–4.472, p = 0.003), hypertension (OR: 2.386, 95% CI: 1.505–3.784, p < 0.001), physical activity disorders (OR: 9.038, 95% CI: 4.462–18.309, p < 0.001) were independent risk factors for CRT in elderly lung cancer patients. Independent risk factors for CRT in elderly lung cancer patients include decreased K-values and decreased R-values, shortened PT, advanced age, elevated platelet count, increased hemoglobin level, surgery ≤ 1 month, male sex, diabetes, hypertension, and physical activity disorders.

Keywords

catheter-related thrombosis - elderly patients - lung cancer - thromboelastography - risk factors

Authors' Contributions

J.J.H. collected, extracted, and analyzed the data, and drafted the manuscript. N.Y. and S.P. assisted in the collation and collection of data. J.M.H., Z.K.S., J.A.W., and X.H. contributed to collect the data. B.B.X., G.Y.M., J.X.L., and H.X.Y. contributed to the interpretation of the manuscript. J.H.Z. conceptualized, designed, and modified the manuscript, being in charge of the direction of this study. All authors contributed to the revisions and agreed to submission of the manuscript to the journal and approved the final submitted version during each stage, and all authors agreed to take responsibility and be accountable for the contents of this work.




Publication History

Received: 15 November 2024

Accepted: 07 April 2025

Article published online:
02 May 2025

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