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DOI: 10.1055/a-2566-1388
Lynch-related adenocarcinoma in a cervical gastric inlet patch
A 65-year-old asymptomatic man with MSH2-related Lynch syndrome underwent routine upper endoscopy. A 13-mm Paris Is sessile lesion, suspected of malignancy, was found in the middle of a cervical gastric inlet patch (GIP) ([Video 1]; [Fig. 1] a). The lesion was removed en bloc by endoscopic submucosal dissection (ESD), using a clip-with-line traction technique ([Fig. 1] b-d). Histology revealed a well-differentiated adenocarcinoma pT1a m2 arising from ectopic gastric metapasia, with free resection margins and no presence of prognostic risk factors for lymph node metastasis ([Fig. 2]). Loss of expression of MSH2 and MSH6 was found, and Helicobacter pylori was absent in the stomach and inlet patch. Surveillance endoscopy at 3 and 12 months showed no local recurrence or metachronous lesions.
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Lynch syndrome is one of the most common hereditary cancer predisposition syndromes, significantly increasing the risk of colonic and extracolonic cancers [1]. Gastric and duodenal cancer has incidences of up to 13% and 11%, respectively, with a higher incidence of gastric cancer in MSH2 mutation carriers [1] [2]. If diagnosed in time, early carcinoma can be successfully treated with ESD, although symptoms often appear late or not at all. Nevertheless, the routine screening of Lynch syndrome patients via esophagogastroduodenoscopy remains debated, with varying guideline recommendations [3] [4] [5]. Additionally, the absence of H. pylori indicates that this is not the only mechanism promoting the development of gastric cancer in Lynch patients, despite H. pylori screening often being the only routine recommendation for screening in multiple guidelines [3] [4] [5]. This case endorses the importance of meticulous endoscopic assessment of not only the stomach and duodenum but also the proximal esophagus, which harbors an underestimated risk when a GIP is present. “Don’t skip the GIP!”
Endoscopy_UCTN_Code_CCL_1AB_2AC_3AB
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Conflict of Interest
R. Bisschops: Pentax, Norgine, Medtronic, Fujifilm, Boston Scientific, Endostart, Ovesco, Olympus, Erbe. J. Jacques: Erbe, Olympus, Fujifilm, Pentax, Boston Scientific. P. Leclercq: Olympus, Erbe, Fujifilm, Medtronic, Boston Scientific.
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References
- 1 Kumar S, Farha N, Burke CA. et al. Upper Gastrointestinal cancer surveillance in Lynch Syndrome. Cancers 2022; 14: 1000
- 2 Aarnio M, Sankila R, Pukkala E. et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 1999; 81: 214-218
- 3 Van Leerdam ME, Roos VH, van Hooft JE. et al. Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2019; 51: 1082-1093
- 4 Stjepanovic N, Moreira L, Carneiro F. et al. Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019; 30: 1558-1571
- 5 Monahan KJ, Bradshaw N, Dolwani S. et al. Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut 2020; 69: 411-444
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Publication History
Article published online:
09 April 2025
© 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).
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References
- 1 Kumar S, Farha N, Burke CA. et al. Upper Gastrointestinal cancer surveillance in Lynch Syndrome. Cancers 2022; 14: 1000
- 2 Aarnio M, Sankila R, Pukkala E. et al. Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 1999; 81: 214-218
- 3 Van Leerdam ME, Roos VH, van Hooft JE. et al. Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2019; 51: 1082-1093
- 4 Stjepanovic N, Moreira L, Carneiro F. et al. Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2019; 30: 1558-1571
- 5 Monahan KJ, Bradshaw N, Dolwani S. et al. Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut 2020; 69: 411-444



