Visible-Light-Driven Gold-Catalyzed Cross-Coupling of Aryl Bromides with Carboxylic Acids

Keywords

aryl bromides - carboxylic acids - cross-coupling - energy transfer - gold catalysis - photocatalysis

Significance

Xia and co-workers report a photosensitized gold-catalyzed protocol for the cross-coupling of aryl bromides with carboxylic acids. The reaction takes place under mild conditions, which is of note considering the usual low reactivity of aryl bromides in gold catalysis.

 

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Comment

Experimental and computational studies revealed that the reaction proceeds via a photoinduced energy transfer (EnT) that enables the oxidative addition of the gold(I) complex to the aryl bromide. A second EnT event facilitates reductive elimination of the aryl–Au(III) complex, thereby closing the catalytic cycle.

 

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Publication History

Article published online:
22 April 2025