Gold(I)-Catalyzed Propargyl Claisen Rearrangement

Keywords

gold(I) catalysis - Claisen rearrangement - homoallenic alcohols

Significance

This study advances gold catalysis by using air‐ and moisture-tolerant gold(I) catalysts for acetylenic Claisen rearrangements. It achieves excellent stereo- and regioselectivity with near-complete chirality transfer, enabling the enantioselective synthesis of allenes.

Comment

By fine-tuning the counterion and structure of the catalyst, the authors achieved high stereo- and regioselectivity, enabling efficient syntheses of enantioenriched compounds. This advances homoallenic alcohol production and complex molecular architectures for pharmaceuticals and materials science.

Publication History

Article published online:
25 March 2025