Scaffold Hopping with IL-17 Antagonists – Exploiting an Oxygen-to-Sulfur Interaction to Favor Planarity

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Synfacts 2025; 21(04): 423
DOI: 10.1055/a-2539-3755

Innovative Drug Discovery and Development

Contributor(s):

Antonia F. Stepan (Roche)

,

Nicholas A. Meanwell (Baruch S. Blumberg Inst., U. Michigan, Rutgers. U.)

scaffold hopping - oxygen-to-sulfur interaction - conformational bias

Article published online:
25 March 2025

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