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Semin Neurol 2025; 45(03): 368-382
DOI: 10.1055/a-2538-3300
DOI: 10.1055/a-2538-3300
Review Article
Restless Legs Syndrome: Neurochemistry and Therapy
Abstract
Restless legs syndrome (RLS) is a complex sensorimotor disorder characterized by disturbances in key neurochemical pathways, including dopaminergic, glutamatergic, and adenosinergic systems. This review provides an overview of the current knowledge on RLS, including its clinical features and diagnosis, pathophysiology, and treatment (non-pharmacological and pharmacological). We examine the association between RLS and neurological disorders, genetic predispositions, and brain iron deficiency. Emerging therapies targeting glutamate and adenosine receptors, alongside established dopamine agonists and α2δ ligands, offer promising avenues for treatment.
Publication History
Article published online:
11 March 2025
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