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Transfusionsmedizin 2025; 15(02): 100-111
DOI: 10.1055/a-2500-8815
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AB0- und Rhesus-Kompatibilität bei der Thrombozytentransfusion

AB0 and Rhesus Compatibility in Platelet Transfusion
Nina Cooper
,
Beate Mayer
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Die Transfusion von Thrombozytenkonzentraten (TK) ist bei schweren Thrombozytopenien und lebensbedrohlichen Blutungen unverzichtbar. Die kurze Haltbarkeit der Präparate und die begrenzte Verfügbarkeit erschweren die AB0-idente und RhD-kompatible Versorgung. Der Artikel erläutert die immunhämatologischen Grundlagen der AB0- und RhD-Inkompatibilität bei der TK-Transfusion und zeigt praktische Strategien zur Risikominimierung bei ABD-inkompatibler Transfusion.

Abstract

The transfusion of platelet concentrates (PC) is essential for patients with severe thrombocytopenia and life-threatening haemorrhages. The short shelf life of PC and their limited availability make it difficult to provide patients with AB0-identical and RhD-compatible PC, as recommended by the German haemotherapy guidelines. In daily practice, PC are often issued on a “first in first out” basis, but it is sometimes difficult to find compatible PCs for patients with rarer blood groups such as B or AB RhD-negative, which raises the question of which incompatibilities are acceptable and which risk minimization strategies should be applied. The PCs used in Germany are leucocyte-depleted and are prepared by the pool or apheresis method using either plasma or a mixture of plasma and a platelet additive solution (PAS). Each product has individual advantages. This article explains the immunohaematological basis of AB0 and RhD incompatibility in platelet transfusion and outlines practical strategies to minimise the risk of ABD incompatible transfusion.

Schlüsselwörter

Thrombozytentransfusion - AB0-Inkompatibilität - RhD-Inkompatibilität - Isoagglutinine - Hämolyse

Key word

platelet transfusion - AB0 incompatibility - RhD incompatibility - isohemagglutinins - Hemolysis


Publication History

Article published online:
14 May 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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