Entschlüsselung des pleiotropen, therapeutischen Potenzials von Adaptogenen

Zusammenfassung

Das reduktionistische Konzept in der Pharmakologie, welches auf der Ligand-Rezeptor-Interaktion basiert, erscheint ein nur wenig geeignetes Modell für Adaptogene zu sein. Medizinalpflanzliche Zubereitungen beeinflussen mehrere physiologische Funktionen, zeigen polyvalente pharmakologische Aktivitäten und werden in der traditionellen Medizin bei vielen Erkrankungen eingesetzt. In dieser Übersichtsarbeit wird zum ersten Mal eine rationale Begründung für die pleiotrope therapeutische Wirksamkeit von Adaptogenen geliefert, welche sich auf Beweise aus aktuellen Genexpressionsstudien in Zielzellen stützt und bei denen die Ansätze der Netzwerkpharmakologie und Systembiologie angewandt wurden. Die spezifischen molekularen Zielmoleküle und die Signalmechanismen der adaptiven Stressreaktion, welche an den unspezifischen Wirkungsweisen von Adaptogenen beteiligt sind, werden identifiziert.

Schlüsselwörter

Netzwerkpharmakologie - Adaptogene - Genexpression - pleiotrope Wirkung - unspezifisch - spezifische Wirkung

Publication History

Article published online:
12 June 2025

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