Safety, Efficacy, and Effectiveness of Maternal Vaccination against Respiratory Infections in Young Infants

Nisha Makan-Murphy; Shabir A Madhi; Ziyaad Dangor

doi:10.1055/a-2471-6906

Seminars in Respiratory and Critical Care Medicine, Table of Contents

Semin Respir Crit Care Med 2025; 46(01): 001-013
DOI: 10.1055/a-2471-6906

Review Article

Safety, Efficacy, and Effectiveness of Maternal Vaccination against Respiratory Infections in Young Infants

Nisha Makan-Murphy

¹South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

,

Shabir A Madhi^*

¹South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

²Wits Infectious Diseases and Oncology Research Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

,

Ziyaad Dangor^*

¹South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

› Author Affiliations

Abstract

Lower respiratory tract infection (LRTI) is a major cause of neonatal morbidity and mortality worldwide. Maternal vaccination is an effective strategy in protecting young infants from LRTI, particularly in the first few months after birth when infant is most vulnerable, and most primary childhood vaccinations have not been administered. Additionally, maternal vaccination protects the mother from illness during pregnancy and the postnatal period, and the developing fetus from adverse outcomes such as stillbirth and prematurity. In this paper, we review the safety, efficacy, and effectiveness of maternal vaccines against LRTIs, such as pertussis, influenza, coronavirus disease 2019, and respiratory syncytial virus.

Keywords

pregnancy - vaccination - safety - immunogenicity - respiratory pathogens

Full Text

References

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