Ethyl Propiolate Mediated Peptide Synthesis

Keywords

ethyl propiolate - peptide synthesis - coupling reagent

Significance

The development of practical, handy, commercially available, inexpensive, and sustainable reagents for peptide synthesis has gained significant attention in organic synthesis. In this paper, the authors used ethyl propiolate as an efficient coupling reagent for peptide synthesis.

 

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Comment

Ethyl propiolate mediated peptide coupling between N-protected amino acids and amino acid esters proceeded smoothly to deliver the desired dipeptides in good yields. This method is simple to carry out, and inexpensive commercially available ethyl propiolate was used for the reaction.

 

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Publication History

Article published online:
20 December 2024