Validity of Diagnosis of Disseminated Intravascular Coagulation Based on International Classification of Diseases Coding in a Claims Database

Abstract

Background

Accuracy in diagnoses recorded using the International Classification of Diseases (ICD) coding is the most important element ensuring the foundation of research using real-world data analyses.

Objective

To evaluate the validity of ICD coding for diagnoses of disseminated intravascular coagulation (DIC) using the International Society on Thrombosis and Haemostasis (ISTH) overt DIC criteria and the Japanese Association for Acute Medicine (JAAM) DIC criteria as reference standards.

Methods

This retrospective observational study included adult hospitalized patients diagnosed as having diseases potentially causing DIC extracted from a part of a large-scale database in Japan. The index test was a diagnosis of DIC based on the ICD-10 codes. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated using ISTH overt DIC criteria and JAAM-2 DIC criteria as the reference standards. We also conducted subgroup analyses according to the underlying diseases.

Results

We included 84,300 patients in this study. In the overall study population, sensitivity, specificity, PPV, and NPV of the ICD-based diagnosis for ISTH criteria were 26.28, 98.10, 35.12, and 97.14%, respectively. In subgroup analyses according to the underlying disease, sensitivity ranged from 9.48 to 52.08%, and specificity ranged from 96.94 to 99.47%. The accuracy of the ICD-based diagnosis for JAAM-2 criteria was similar to that for ISTH criteria.

Conclusion

Identification of DIC patients using ICD-10 codes had relatively low sensitivity but very high specificity for DIC diagnostic criteria. Approximately 65% of patients identified by ICD coding are likely to meet the JAAM-2 DIC criteria.

Keywords

disseminated intravascular coagulation - diagnosis - sepsis - leukemia - cancer

Data Availability Statement

The statistical codes and full dataset are available from the corresponding author.

Authors' Contribution

Y.U. conceived and designed this study; contributed to acquisition, shaping data, analyses, and interpretation of the results; and was responsible for drafting, editing, and submission of the manuscript. K.Y. and H.M. contributed to the study design; acquisition, analysis, and interpretation of the data; and drafting of the manuscript. K.O., J.O., and S.F. contributed to interpretation of the data and critical appraisal of the manuscript. All of the authors reviewed, discussed, and approved the final manuscript.

Publikationsverlauf

Eingereicht: 10. Juni 2024

Angenommen: 29. Oktober 2024

Accepted Manuscript online:
29. Oktober 2024

Artikel online veröffentlicht:
18. November 2024

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