Chirurgische Therapie des Oropharynxkarzinoms: Empfehlungen der aktuellen S3-Leitlinie – Teil I

Andreas Dietz; Markus Pirlich; Matthäus Stöhr; Veit Zebralla; Susanne Wiegand

doi:10.1055/a-2223-4083

Laryngo-Rhino-Otologie, Table of Contents

Laryngorhinootologie 2024; 103(08): 599-612
DOI: 10.1055/a-2223-4083

Facharztwissen HNO

Chirurgische Therapie des Oropharynxkarzinoms: Empfehlungen der aktuellen S3-Leitlinie – Teil I

Surgical Treatment of Oropharyngeal Cancer – Recommendations of the Current German S3 Guideline, Part I

Andreas Dietz

,

Markus Pirlich

,

Matthäus Stöhr

,

Veit Zebralla

¹Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Universitätsklinikum Leipzig AöR, Leipzig, Germany

,

Susanne Wiegand

› Author Affiliations

Abstract

Generell ist für das Oropharynxkarzinom in den letzten 2 Dekaden ein Trend zur transoralen Resektion + Neck Dissection + adjuvante Radio(chemo)therapie zu verzeichnen. Auf Basis der aktuell verfügbaren besten Evidenz aus Registerstudien können Empfehlungen ausgesprochen werden, wobei die aktuelle Datenlage mit gebotener Zurückhaltung bewertet werden sollte, weil bisher manche bedeutenden Parameter keinen Eingang in die Berechnung gefunden haben.

Abstract

In general, a trend towards transoral resection (as opposed to classic open approaches) + neck dissection + adjuvant radio- (chemo-) therapy has been observed for oropharyngeal carcinoma over the last 20 years. Techniques of transoral surgery (TOS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS) have been propagated in retrospective comparisons with conventional surgery or primary radiochemotherapy as gentle, minimally invasive procedures with good late functional results. Meta-analyses of mostly uncontrolled retrospective analyses suggest that TORS may have better disease-free survival (DFS) and a reduced risk of free flap reconstruction compared with open surgery. TORS (TOS) was associated with fewer tumor-positive resection margins (R1), a lower number of recurrences, fewer intraoperative tracheostomies, a shorter inpatient stay and a shorter duration of postoperative nasal tube feeding compared to open surgery. In principle, based on the best evidence currently available from registry studies, stage I-II oropharyngeal carcinomas can be treated either with primary surgery or radiochemotherapy with a comparable chance of survival. With comparable evidence for stage III and IVa, p16neg. oropharyngeal carcinomas, the majority of authors advocate primary surgery followed by adjuvant radiotherapy or radiochemotherapy as the treatment of first choice. For p16pos. patients the results of registry studies are inconsistent, although the largest registry study on 450 HPV-positive stage III patients shows a significant superiority of primary surgery + adjuvant radiochemotherapy. Since all registry studies did not adjust for smoking status, among other factors, the current data situation should be evaluated with the necessary caution.

Schlüsselwörter

Oropharynxkarzinom - p16 - HPV-16 - Kopf-Hals-Chirurgie - transorale Chirurgie - TORS - TLM

Keywords

Oropharyngeal carcinoma - p16 - HPV-16 - head and neck surgery - transoral surgery - TORS - TLM

Full Text

References

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