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Tierarztl Prax Ausg K Kleintiere Heimtiere 2023; 51(05): 361-367
DOI: 10.1055/a-2174-6948
Case Report

Extensive fatal Pyoderma gangrenosum in a dog after drug exposure

Generalisierte fatale Pyoderma gangrenosum bei einem Hund nach Medikamentenexposition
Laura Schaefer
1   Small Animal Clinic, Justus Liebig University, Giessen, Germany
,
Elena Kloß
2   Institute of Veterinary Pathology, Justus Liebig University, Giessen, Germany
,
Manfred Henrich
2   Institute of Veterinary Pathology, Justus Liebig University, Giessen, Germany
,
Nina Thom
1   Small Animal Clinic, Justus Liebig University, Giessen, Germany
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Abstract

A 4-year-old, spayed female mixed breed dog was presented with large crater-like, well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated body temperature and lethargy, that began 14 days after vaccination and treatment with fluralaner and milbemycin/praziquantel. Cytology revealed severe pyogranulomatous inflammation with moderate numbers of extracellular microorganisms. Histopathologic examination showed severe multifocal pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe neutrophilic exocytosis with band-like infiltration of the lower portion of the epidermis consistent with pyoderma gangrenosum. Despite intensive immunosuppressive and antimicrobial therapy and intensive inpatient care, the dog was euthanized 16 days after admission due to complications with clinical signs of sepsis, acute dyspnea and thoracic effusion.

Zusammenfassung

Eine 4 Jahre alte kastrierte Mischlingshündin wurde mit krater-artigen, gut demarkierten, erosiven bis ulzerativen nekrotischen Hautläsionen, erhöhter Körperinnentemperatur und Lethargie vorgestellt. Die Symptome traten 14 Tage nach einer Impfung und der Verabreichung von Fluralaner und Milbemyzin/Praziquantel auf. In der zytologischen Untersuchung stellte sich eine schwere pyogranulomatöse Entzündung ohne Nachweis von Mikroorganismen dar. In der Hautbiopsie zeigte sich eine hochgradige, multifokale, pyogranulomatöse Dermatitis und Pannikulitis mit ausgeprägtem dermalem Ödem und hochgradiger neutrophiler Exozytose mit bandartiger Infiltration der tiefen Epidermisschichten. Die Diagnose eines Pyoderma gangrenosum wurde gestellt. Trotz stationärer immunsuppressiver und antimikrobieller Therapie wurde die Hündin 16 Tage nach der Vorstellung aufgrund von Symptomen einer Sepsis mit akuter Atemnot und Thoraxerguss euthanasiert.

Key words

Canine - neutrophilic dermatosis - adverse drug reactions - nosocomial infections

Schlüsselwörter

Canine - neutrophile Dermatose - Medikamentenreaktionen - nosokomiale Infektionen


Publikationsverlauf

Eingereicht: 11. Januar 2023

Angenommen: 23. März 2023

Artikel online veröffentlicht:
13. November 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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