Extensive fatal Pyoderma gangrenosum in a dog after drug exposure

Abstract

A 4-year-old, spayed female mixed breed dog was presented with large crater-like, well-demarcated, erosive and ulcerative necrotic lesions of the skin, elevated body temperature and lethargy, that began 14 days after vaccination and treatment with fluralaner and milbemycin/praziquantel. Cytology revealed severe pyogranulomatous inflammation with moderate numbers of extracellular microorganisms. Histopathologic examination showed severe multifocal pyogranulomatous dermatitis and panniculitis with severe dermal edema and severe neutrophilic exocytosis with band-like infiltration of the lower portion of the epidermis consistent with pyoderma gangrenosum. Despite intensive immunosuppressive and antimicrobial therapy and intensive inpatient care, the dog was euthanized 16 days after admission due to complications with clinical signs of sepsis, acute dyspnea and thoracic effusion.

Zusammenfassung

Eine 4 Jahre alte kastrierte Mischlingshündin wurde mit krater-artigen, gut demarkierten, erosiven bis ulzerativen nekrotischen Hautläsionen, erhöhter Körperinnentemperatur und Lethargie vorgestellt. Die Symptome traten 14 Tage nach einer Impfung und der Verabreichung von Fluralaner und Milbemyzin/Praziquantel auf. In der zytologischen Untersuchung stellte sich eine schwere pyogranulomatöse Entzündung ohne Nachweis von Mikroorganismen dar. In der Hautbiopsie zeigte sich eine hochgradige, multifokale, pyogranulomatöse Dermatitis und Pannikulitis mit ausgeprägtem dermalem Ödem und hochgradiger neutrophiler Exozytose mit bandartiger Infiltration der tiefen Epidermisschichten. Die Diagnose eines Pyoderma gangrenosum wurde gestellt. Trotz stationärer immunsuppressiver und antimikrobieller Therapie wurde die Hündin 16 Tage nach der Vorstellung aufgrund von Symptomen einer Sepsis mit akuter Atemnot und Thoraxerguss euthanasiert.

Key words

Canine - neutrophilic dermatosis - adverse drug reactions - nosocomial infections

Schlüsselwörter

Canine - neutrophile Dermatose - Medikamentenreaktionen - nosokomiale Infektionen

Publication History

Received: 11 January 2023

Accepted: 23 March 2023

Article published online:
13 November 2023

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