Planta Med 2024; 90(01): 47-62
DOI: 10.1055/a-2157-8913
Natural Product Chemistry and Analytical Studies
Reviews

Review: The Chemistry, Toxicity and Antibacterial Activity of Curcumin and Its Analogues

Hannah J. Denison
1   Syngenta, Jealottʼs Hill International Research Centre, Bracknell, Berkshire, UK
,
Sianne L. Schwikkard
2   Department of Chemical and Pharmaceutical Science, Kingston University, London, UK
,
Mouhamad Khoder
3   Department of Pharmacy, Kingston University, London, UK
,
4   Department of Applied and Human Sciences, Kingston University, London, UK
› Author Affiliations
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Abstract

Antimicrobial resistance is a global challenge that is already exacting a heavy price both in terms of human health and financial cost. Novel ways of approaching this crisis include the investigation of natural products. Curcumin is the major constituent in turmeric, and it is commonly used in the preparation of Asian cuisine. In addition, it possesses a wide range of pharmacological properties. This review provides a detailed account of curcumin and its analoguesʼ antibacterial activity against both gram-positive and gram-negative isolates, including its potential mechanism(s) of action and the safety and toxicity in human and animal models. We also highlight the key challenges in terms of solubility/bioavailability associated with the use of curcumin and include research on how these challenges have been overcome.



Publication History

Received: 18 April 2023

Accepted after revision: 19 August 2023

Accepted Manuscript online:
21 August 2023

Article published online:
28 September 2023

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